LOCUS       ERZ1687568.209-NODE-209-length-18519-cov-2.702123 13947 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  ERZ1687568.209-NODE-209-length-18519-cov-2.702123.
ACCESSION   ERZ1687568.209-NODE-209-length-18519-cov-2.702123
VERSION     ERZ1687568.209-NODE-209-length-18519-cov-2.702123
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.0.0beta2
            Run date     :: 2023-04-19 02:04:30
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13947
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1701
                     /locus_tag="ctg209_1"
                     /transl_table=11
                     /translation="LPGCYSLLSFSGEEAVTRECLIQNQNDCVVIVVDCGVIERNLSFA
                     LQVLSVIKNAVLCLNLCDEAEKNGIKIDCDELSLNLGIPVVKTCATDKKGLDELKKAIY
                     NVCSGKTKCFRVERNFEGVDILSEKNYKQNIEKLSQIGNKISSDCVKYEKSELNACTRK
                     LDKILASKTTGIPIMLAMLGILFWITVVGANYPSEWLSNLFGFIKEKLYILFDFLHAPD
                     VVTGLLIDGVYTTLSWVVSVMLPPMAIFFPLFSLVEDSGYLPRIAFNLDRYFSKCGAHG
                     KQSLAMAMGLGCNACGVTGCRIIESPKERLIAILTNNFMPCNGRFPTIIALLLMFFAGT
                     AFTLSSSLEVAALLIGIIVFCVFITLVISKVLSVTILKGEQSGFVLELPPYRKPQILKT
                     IVRSLLDRTLFVLGRAVAVAAPAGAIIWILANVHISDVSLLKYCTDFLDPFGRFIGVDG
                     VIIMAFILGFPANETVIPIIIMSYMASGTLVDYSSYDQLFQLLNMNGWTITTAVCTIIL
                     CILHYPCSTTCLTIKKETGSLKWTLVSMALPTAMGIVLCMITAGVMRLF"
     protocluster    1..13947
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2567:3947]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2568..3947
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..13947
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13947
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             complement(1693..2499)
                     /locus_tag="ctg209_2"
                     /transl_table=11
                     /translation="MNEKIIMLGTGSAMVTDCYNTCFLLKSENDCLLVDAGGNGILSAI
                     KKSGIAWNSIKTMFITHSHTDHILGAVWVIRQISALMNSGKYDGNFNIYCHDECVDSIT
                     AICNHTLAPKFLKNINTKIFVNEVKDGEMQNAGSIQLTFFDIFSDKTKQFGFKAVFPSG
                     KVLACLGDEPFNEKCRNFVQNCDYLMCEAFCLYSQKDIFKPYEKFHSTALDAGKLAESL
                     FAKNLILYHTEDETLQTRKRTYTSEARTVFNGNIFVPDDFEVINLK"
     CDS             complement(2568..3947)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg209_3"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 1.8e-31,
                     bitscore: 98.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.9e-15, bitscore: 46.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.1e-15, bitscore: 46.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.5e-20, bitscore:
                     63.8, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHQYKLNGYNIVLDVYSGSVHAVDDLAYDVIAMYKNATKEQIID
                     EMLSKYADNPEITKEEISDCIDDVKELEEQGKLFTDDKYENLAFDFKKRNTVIKALCLH
                     IAHTCNLNCEYCFASQGKYHGERALMSFEVGKRAIDFLIENSGSRVNLEVDFFGGEPLM
                     NFDVVKQIVAYARSIEKEHNKNFRFTLTTNGMLVDDDVIEFANKECHNVVLSLDGRKEV
                     HDHLRKTVNGKGSYDIIVPKFQEFVKKRGNKGYYVRGTYTHNNTDFTNDIFHMADLGFT
                     ELSMEPVVCAPDDPYALTYDDLPILFEQYEILAKEMLKREKEGRPLTFYHYMIDLTGGP
                     CIYKRISGCGSGTEYMAVTPWGDLYPCHQFVGDEKYKLGDIFNGVSNTKIQDEFKLCNA
                     YARPDCKDCWARLYCSGGCAANAYHATGSITGIYEYGCELFRKRMECAIMMKVAEAEAE
                     E"
     CDS             complement(4243..5646)
                     /NRPS_PKS="Domain: Aminotran_5 (54-217). E-value: 3.1e-13.
                     Score: 41.2. Matches aSDomain:
                     nrpspksdomains_ctg209_4_Aminotran_5.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg209_4"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.7e-12, bitscore:
                     36.7, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.1e-09,
                     bitscore: 28.2, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 1.6e-13, bitscore:
                     40.5, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYDKLKNYSKSGIYPFHMPGHKRTDITEEGIIPYNIDITEIHDF
                     DNLHSPNGVIDEIQKKAAKLYNAKNAFILINGSTGGILSAIRSMTNQGDKILMARNCHK
                     SVYNSAELFNLNVDYIFPDTDSRYNILTSVSPCDIEDKLTKHNDEIRLVIITSPTYEGV
                     VSDIKSISEICHKHGAKLLVDEAHGAHFPFSDSFPDEALNCGADAAVLSLHKTLPSLTQ
                     TALLITNDSELSEIIAENLAVFETSSPSYILMSSIEKCLDFCENSKDKFKEYCCNLKTV
                     REKLKNLKYLKIYDKSDTDFDYDIGKIVISTANANISGTKLAEILRNNYQIETEMAYSD
                     YVIAMASVCDTEKAFNMLSDALISIDSELSKGADTERVPLKNLYTGKNFNACELYKFNK
                     ETISFQNSEFRTSAEYIWAYPPGIPLIVPGEIISKELINYIEYLSACKVEIMSTKGGMT
                     DNISVVKKD"
     aSDomain        complement(4996..5484)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg209_4_Aminotran_5.1"
                     /evalue="3.10E-13"
                     /label="ctg209_4_Aminotran_5.1"
                     /locus_tag="ctg209_4"
                     /protein_end="217"
                     /protein_start="54"
                     /score="41.2"
                     /tool="antismash"
                     /translation="IDEIQKKAAKLYNAKNAFILINGSTGGILSAIRSMTNQGDKILMA
                     RNCHKSVYNSAELFNLNVDYIFPDTDSRYNILTSVSPCDIEDKLTKHNDEIRLVIITSP
                     TYEGVVSDIKSISEICHKHGAKLLVDEAHGAHFPFSDSFPDEALNCGADAAVLSLHKTL
                     "
     CDS             complement(5670..7256)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190:GTP-binding protein LepA (Score: 109.2; E-value:
                     4e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg209_5"
                     /transl_table=11
                     /translation="MSSFKEEISKRRTFAIISHPDAGKTTLTEKLLLYGGAINLAGSVK
                     GKRTAKHAVSDWMEIEKQRGISVTSSVLQFKYNGYCINILDTPGHEDFSEDTYRTLMAA
                     DSAVMVIDGSKGVEKQTIKLFKVCVMRNIPIITFINKMDRDAKNSFDLLEDIENVLGIH
                     TYPVNWPIGSGKEFKGVYDRNSKKILAFTANNGQKEVEKKELTLDDPALEDTIGYYHKQ
                     DLFDEIELLDGAGDEFDLEAVRNGQLTPVFFGSALTNFGVEPFLEQFLQLTTPPLPRET
                     VDEKVEPMSDFFSAFVFKIQANMNKAHRDRVAFMRICSGKFEKNMEVFHVQGNKKMRLS
                     QPQQIMAQEREIVDEAYAGDIIGVFDPGIFSIGDTICSPGHKVQFRGIPTFAPEHFALV
                     RQKDTMKRKQFIKGTSQIAQEGAIQIFQELDAGMEEVIVGVVGVLQFDVLKYRLQNEYN
                     CDIIMETLPYEFIRWIVNDDLDPKTLDLASDTKKIQDLKGNHLLLFTSYWSINWALEHN
                     KGLELAEFGTN"
     CDS             7422..8606
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg209_6"
                     /sec_met_domain="PF04055 (E-value: 2.6e-19, bitscore: 60.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VIFPIFSYTFQIEAETCVSASKSFMRFFMSNSIGLYIHIPFCKHK
                     CPYCDFFSWNADENAFDNYVIELKDKIKYWSEKAKRDVATVYFGGGTPSVLGADRLCDI
                     LDFIKFNFNIQNNAEITVEVNPDSAKTIDFKKMYACGFNRISMGMQTAVEDELRLLGRI
                     HSIDDANTSVERAKSAGFNNISLDLMMGIPNQTIESLEKSISFCADCKVTHISSYILKI
                     EENTPFYKAQNKLKLADDDMQAEMYLKAVEMLDSLGYKQYEISNFAKQGYESRHNTNYW
                     RCGEYIGIGPSAHSFFEGKRFFYSRSMDDFNNNKLSFEGTGGDEEEFIMLSLRLKSGLN
                     YSEFEEKFGYTLPSYIIKKAKEYEKYGYTNVTDKSISFTPKGFLVSNSIISELI"
     CDS             complement(8666..9565)
                     /locus_tag="ctg209_7"
                     /transl_table=11
                     /translation="MKFCKYCGAQLEDNAVCNCEKSRAAQAQAQQANAQAQPQYQQPVQ
                     PQQPQYQNPVQQQYAQPQSPQTQQSPYAVNNTAPIGENAFVKALKNIPVVFTSFFKDSK
                     TVIKTAKAEKDIILSALFSAIFFIALILGNMFLMLSMSALDFPKTLLVSLVTAVLIGGF
                     YSVILFAYVKKYKTEENTAKAFIDSFITFSIESIPASIGWILAGLCALISVYMFLFFFV
                     IVMLYLVISLVNQVKANVPEAKNSALFTLILTLIVAVAFMIVFFIGAKLTMWSFNTSTF
                     TTSVLTSLIGGGSYPSLY"
     CDS             complement(9817..10524)
                     /locus_tag="ctg209_8"
                     /transl_table=11
                     /translation="MDNSSNMTVNTTQITNQINPEHHYGLDKNKACLNNSCPSNTADIG
                     CYIPAIDEIMRHNQGAPSVAHPNMTEKVQKSNDNPSLEQAEIAYEEGGSTSEEQPENIN
                     KYSGSLQTIPFIKDLKKIDTSIPVLPATPATTASSGATVATPIRQNIGMSMSDYQYPFP
                     VTAENLRYHNGFMRTQIGRRITVDFLMGANTIVQKTGYLLGVAQDYILINEIDTNDITT
                     CDYYNIKFIRYYY"
     CDS             complement(10539..10982)
                     /locus_tag="ctg209_9"
                     /transl_table=11
                     /translation="VALSTRELLARLLKCEAGGEGENGMRAVASVIVNRTRVPDGEFAR
                     VSKGGDFRAIMEQPNQFTCLKTTVGGQYNPQNVYNIRPDEIHYNIADWALAGNTDSSVG
                     NSIFYFNPFSDTCPTFFPSNNGVIYNRVGDHCFYSPTEAYSET"
     CDS             complement(11176..11493)
                     /locus_tag="ctg209_10"
                     /transl_table=11
                     /translation="MDEEYDDWLVNDDGKNNINDLIKETVALETTGKTGFFYLDKKRTQ
                     NIFKKSGYQLPSRLKNSGSNIIIRTIDDSVNKKSIILLKANNLSDGSVIGKIALQKQVK
                     R"
     CDS             complement(11704..12084)
                     /locus_tag="ctg209_11"
                     /transl_table=11
                     /translation="LVILGFEINPKHGGKFSEVLTAEEWRKFTHAMSTGLDSGLRINDN
                     SILVECEVDSKYQYKLVIYDNTFDDNPLEKVYAIRNIDYNITDGNKIANFIIKLEENNY
                     DSKKVFRQLLRDYTKQFELILG"
     CDS             12503..12622
                     /locus_tag="ctg209_12"
                     /transl_table=11
                     /translation="MLDFADIFLKIMYEKIIETTILKLSIGTTALAGLSCKTL"
ORIGIN
        1 ttaccgggat gctattccct gctttcattt tcgggcgaag aggcggtaac aagggagtgt
       61 cttatacaaa atcaaaatga ctgcgttgta atagttgttg actgcggagt tattgaaaga
      121 aatctttcat ttgcattgca ggtgttatct gtcataaaga atgctgttct ttgtcttaat
      181 ctttgtgatg aggctgaaaa aaacggtata aaaatcgact gcgacgagtt atcgctaaat
      241 cttggaatac ctgttgtaaa aacctgtgca acagacaaaa aaggtttgga tgagttaaaa
      301 aaagcgatct ataatgtatg cagcggaaag acaaaatgtt ttagggtaga aagaaatttt
      361 gaaggtgttg atatactatc cgaaaaaaac tacaaacaga atattgaaaa gctttcgcag
      421 attggcaaca aaatttcaag tgactgcgta aaatatgaaa aatcagagtt aaatgcttgt
      481 acaagaaagc ttgataaaat acttgcaagc aaaaccacgg gaataccgat tatgcttgca
      541 atgcttggta tattgttctg gataacagtt gtcggtgcaa attatccgag cgaatggtta
      601 agcaatttgt ttggctttat aaaagagaaa ctgtatattc tttttgattt tttacacgct
      661 cccgatgttg taacgggact tttgattgac ggagtttata caactctgtc atgggtggta
      721 tctgtaatgc tgccgcctat ggctatattc tttccgttgt tttcgcttgt tgaggattcg
      781 ggatatctgc cgagaattgc atttaatctt gataggtatt tttcaaagtg cggtgctcac
      841 ggaaagcaaa gtcttgctat ggcaatgggg cttggctgta atgcctgcgg agttacggga
      901 tgcagaatta ttgagtcgcc aaaggaacga ctgattgcaa ttcttacaaa taattttatg
      961 ccgtgtaatg gacggtttcc cacaataatt gcattactgc tcatgttctt tgcaggtacg
     1021 gcatttacgc tgagcagttc gcttgaggta gcggcattgt tgattggaat aatagttttc
     1081 tgtgttttta taacacttgt tatatctaag gtactttcag tcacaatatt gaaaggcgaa
     1141 cagtccggat ttgtgcttga gcttccgccg tacagaaagc cgcagatttt aaaaactatt
     1201 gtccgttcgc tgttggacag aactttattt gttttaggaa gggctgttgc ggttgccgct
     1261 ccggcaggtg cgataatttg gattcttgca aatgtgcata taagcgatgt ttcactttta
     1321 aaatattgta ctgatttttt agatccgttc ggcagattta tcggggttga cggcgttata
     1381 ataatggcat ttatacttgg atttcctgct aatgaaaccg ttattccgat tataattatg
     1441 tcatatatgg caagcggtac tcttgttgat tattcaagct atgatcagct gtttcaactt
     1501 ctcaatatga acggctggac gattacaacg gctgtatgca cgattattct ttgcattctt
     1561 cattatccgt gttcaacaac ctgtctgaca ataaaaaaag aaacaggcag ccttaaatgg
     1621 acgcttgttt ctatggcatt gcctactgca atgggaattg tactttgtat gattacagca
     1681 ggtgttatga gattatttta agttaataac ttcaaaatca tcgggaacaa atatatttcc
     1741 gttaaaaact gttcttgcct ctgaagtata tgttcttttg cgtgtttgaa gtgtttcgtc
     1801 ctcggtgtga tacaggataa gattttttgc aaaaagactc tctgcaagtt ttcctgcatc
     1861 aagtgctgtg ctgtgaaatt tttcgtaagg cttaaaaata tctttttgac tgtaaagaca
     1921 aaaagcttca cacataagat aatcacagtt ttgaacaaaa tttctgcatt tttcattgaa
     1981 cggttcatca ccgagacagg cgagaacttt tcctgacgga aaaacagcct tgaatccgaa
     2041 ttgctttgtt ttgtctgaaa atatatcaaa gaaagtgagt tggatactgc cggcattttg
     2101 catttcaccg tcttttactt cattgacgaa aatttttgta ttgatatttt tgagaaattt
     2161 cggtgcgagt gtgtggttgc aaattgccgt gattgaatca acacattcat cgtggcagta
     2221 aatattaaaa ttaccgtcat atttgcctga attcataaga gcgcttattt gccttattac
     2281 ccacacggca cctaatatat ggtcggtgtg agaatgagta ataaacattg tctttatgct
     2341 gttccaagct attccggatt tcttaattgc ggataaaatt ccgtttccgc ctgcgtcaac
     2401 aagaagacag tcgttttcgg atttcagaag aaaacaggta ttataacagt cggtaaccat
     2461 cgcacttcct gtaccgagca taataatttt ttcgttcata cagcacctcg aaaatacagg
     2521 cagatacaag aaaaatgtat ctgcctgcaa atttttttat tgtaatttta ttcttctgct
     2581 tctgcttctg caaccttcat cataatggca cattccattc tttttctgaa aagctcacag
     2641 ccgtattcgt aaatacctgt gattgagcct gttgcatgat aagcgtttgc ggcacaaccg
     2701 ccgctgcaat aaagtcttgc ccagcagtct ttgcagtcag gacgggcgta tgcgttacaa
     2761 agcttaaatt cgtcctgaat tttcgtgttt gaaacaccgt taaagatatc gccgagcttg
     2821 tacttttcat cacctacaaa ttgatgacag ggatagaggt ccccccaagg tgttacagcc
     2881 atatattctg tacccgaacc gcaacccgag attctcttat aaatgcacgg accgcctgta
     2941 aggtcaatca tataatgata gaaggtgagc ggtctgccct ctttttcacg cttgagcatt
     3001 tcctttgcaa gaatttcgta ctgttcaaaa aggataggca aatcatcata tgtaagtgca
     3061 tatgggtcat cgggagcaca tacaaccggc tccattgaaa gctctgtaaa tcccaaatcc
     3121 gccatatgga aaatatcgtt tgtgaagtct gtgttattat gtgtataagt gcctcttaca
     3181 tagtaaccct tgttgcctct ttttttgaca aattcctgaa atttcggaac gataatgtca
     3241 taactgccct ttccgtttac agttttgcga agatggtcat gcacttcttt tctgccgtca
     3301 aggctgagaa ctacattatg acattctttg tttgcaaatt caattacatc gtcatcaaca
     3361 agcataccgt ttgttgtaag tgtaaaacgg aagtttttgt tgtgttcctt ttcaatgctt
     3421 cttgcatagg caacaatctg ctttacaaca tcaaagttca taagaggttc tccgccgaag
     3481 aagtcaacct caaggtttac tctgctgcct gaattttcaa tgagaaagtc aattgctctc
     3541 ttgcccactt caaagctcat cagcgctctc tcgccgtggt atttgccctg acttgcaaag
     3601 cagtattcgc agttaaggtt acaggtgtga gcaatgtgaa gacaaagtgc tttgattact
     3661 gtgtttctct ttttaaagtc aaatgcaagg ttttcgtact tgtcgtctgt aaagagcttt
     3721 ccctgttcct caagctcttt tacatcatca atgcagtcag agatttcttc ttttgtaatc
     3781 tcaggattgt ctgcatattt tgaaagcatt tcgtcgatta tctgttcttt tgttgcgttt
     3841 ttgtacattg caataacatc ataagcaagg tcatcgactg cgtgtacact gccgctgtaa
     3901 acatcaagaa ctatgttgta tccgttaagt ttatactgat gaatcataat atctccgtta
     3961 gacaaaagga aagccgttaa ccctttggga aaacggcgat aatccttaat aatcaaatta
     4021 aaatagaatt atttctcgct catgcacttt tcgcactgct ggttagcaac gccgcaagat
     4081 gtcttacaag ctgactgaca tgaagtctgg cactcgccgc aaccgcctgt cttaacgctc
     4141 ttcttgaggt cacgagtttc gatagtttta attctcttca taataaatca aactccttgt
     4201 tagattttgt tagtttaata ttatcacaca gctattgatt tgtcaatctt ttttaactac
     4261 gcttatgttg tccgtcatac cgccttttgt tgacataatc tcaaccttgc aggctgaaag
     4321 atattcaatg taatttataa gttccttgct tataatttca ccgggtacga tgaggggaat
     4381 tccgggtgga tatgcccaga tatactcggc agaagttctg aattccgaat tttgaaacga
     4441 aatagtttct ttgttgaatt tgtacaactc gcaggcgttg aaatttttgc ctgtgtagag
     4501 attttttaac ggaacacgct cggtgtcggc tccttttgaa agttcgctgt caattgaaat
     4561 cagagcgtct gaaagcatat taaaagcttt ttcagtgtca caaacagatg ccatggcaat
     4621 tacatagtcc gaatatgcca tttcggtttc aatctgataa ttatttcgca gtatttcggc
     4681 aagctttgtt cccgaaatat ttgcgttcgc tgttgaaatt acaattttgc cgatatcata
     4741 atcaaaatca gtatcgcttt tatcataaat tttcagatat tttagatttt taagtttttc
     4801 cctgaccgtt ttaagattgc aacaatattc cttgaattta tctttgctgt tttcgcagaa
     4861 atcaagacat ttttcgattg aactcattaa aatatatgat ggactgcttg tttcaaatac
     4921 agccaaattt tcggcaataa tttcagaaag ctcgctgtca tttgttatga gcaatgcagt
     4981 ttgagttaat gacggcaaag ttttgtgcag actcaatact gcggcgtctg caccgcagtt
     5041 aagtgcttca tcgggaaaac tgtccgaaaa cggaaaatgc gctccgtgag cttcgtcaac
     5101 aagtaatttt gctccgtgtt tgtgacagat ttcggagatt gactttatat ccgaaacaac
     5161 tccttcatat gtaggcgaag ttatgattac aagtctgatt tcatcattgt gttttgtaag
     5221 tttatcttct atatcgcaag gtgaaaccga tgtaagaata ttgtatctgc tgtctgtatc
     5281 gggaaaaatg taatcgacat tgagattaaa cagttctgct gaattatata cagatttgtg
     5341 gcagttacga gccattaaga tcttgtcgcc ttgatttgtc attgagcgaa ttgctgaaag
     5401 tattccgcct gttgaaccgt taatcagaat gaaagcattt tttgcattgt aaagttttgc
     5461 agcctttttc tgaatttcgt caataactcc gtttggtgaa tggagattgt caaaatcatg
     5521 gatttcggtt atgtcgatat tatacggtat tataccctct tctgtaatgt ccgttctttt
     5581 gtgtccgggc atatgaaaag gatatatgcc gctttttgaa taatttttaa gcttgtcgta
     5641 cagcatatat cctccgatat tttaaatatt tagtttgtac cgaactcagc gagttcaagt
     5701 cccttgttgt gttcaagcgc ccagtttatg ctccagtagc ttgtaaagag caaaagatga
     5761 ttgcctttaa gatcctgaat tttcttagta tcggacgcaa ggtcgagagt tttcggatca
     5821 aggtcatcgt ttacaatcca acggataaat tcatacggga gtgtttccat aatgatatca
     5881 cagttgtact cgttttgaag tctgtattta agaacatcaa actgaagtac gcctacaacg
     5941 ccaacgataa cttcctccat acctgcgtca agctcctgga aaatctgaat tgcaccttcc
     6001 tgtgcaatct gacttgtacc cttgatgaac tgtttgcgct tcattgtgtc tttctgacgg
     6061 acaagtgcaa agtgttcggg agcaaatgta ggaattcccc tgaactgtac cttgtgtccc
     6121 ggtgaacaga ttgtgtctcc gattgagaaa atgcccggat caaacacacc gataatgtcg
     6181 cccgcatatg cctcgtcaac aatttctctt tcctgagcca taatctgctg tggctgtgaa
     6241 agacgcattt ttttgttgcc ctgaacatgg aacacttcca tattcttttc aaacttgccg
     6301 ctgcagatgc gcataaatgc aactctgtca cggtgagcct tattcatgtt tgcctgaatt
     6361 ttgaaaacaa atgcagagaa aaagtctgac ataggctcaa ccttttcatc aactgtttct
     6421 cttggcagag gtggagttgt gagctgtaag aactgttcaa ggaatggttc aacaccaaag
     6481 tttgtaagag ccgaaccgaa gaatacagga gtaagctgac cgttgcggac tgcttcaagg
     6541 tcaaattcat cgcctgcacc gtcaagaagt tctatttcat caaacaaatc ctgcttatga
     6601 tagtagccta ttgtatcttc aagggcagga tcgtcaagcg taagttcttt cttttcaact
     6661 tctttctgac cgttattagc ggtgaaagca aggattttct tagaatttct gtcatacaca
     6721 cccttgaatt ccttacctga accgattggc cagtttacgg gataggtgtg aattccgaga
     6781 acattttcaa tgtcttcaag aaggtcaaaa gaatttttgg catctctgtc catcttgttg
     6841 atgaatgtaa tgataggaat attacgcatt acacagacct tgaaaagttt gatagtctgt
     6901 ttttcaacac cctttgaacc gtcaattacc attacggcag agtctgccgc cataagtgta
     6961 cggtaggtat cttccgagaa gtcctcatgt cccggtgtat caagaatatt tatgcaataa
     7021 ccgttatatt taaactgcaa aaccgatgat gtaacagaaa taccacgctg tttttcaatt
     7081 tccatccagt cggacacagc atgctttgcg gttcttttgc cttttaccga acctgcaagg
     7141 ttaattgctc cgccgtagag caagagcttt tctgtaagtg ttgttttacc cgcatcagga
     7201 tgcgaaataa tcgcaaaggt tctgcgcttg ctgatttctt ctttaaatga actcatatct
     7261 ttcttccctt cggaggttaa gtatatccac aattctatat tttactattt ttggatggta
     7321 tatgtcaata aagaatgaag aaaatgtgag aaaaataatt gctacaaaaa cttgacaaat
     7381 ttgtaaatat attgtaatat attggtacag aaggacttaa tgtgattttt cctatttttt
     7441 catatacctt ccaaatcgag gcagaaactt gtgtttctgc ctcaaaatca tttatgaggt
     7501 tttttatgag taattctatc ggtctttaca ttcacatacc gttttgtaag cacaaatgtc
     7561 cgtattgcga ttttttcagc tggaatgcag acgaaaacgc tttcgataat tatgtgattg
     7621 aattaaaaga taaaataaaa tactggtctg aaaaagccaa aagagatgtt gcgaccgtat
     7681 atttcggcgg tggtacgccg agtgttttag gtgcagacag gctttgtgat attcttgatt
     7741 ttatcaagtt taattttaat attcaaaata atgccgagat tacggttgaa gtcaatcccg
     7801 actccgccaa aactattgat tttaaaaaaa tgtatgcctg cggatttaat cgcatttcaa
     7861 tgggaatgca gactgctgtt gaagatgaat taaggctgct tgggagaatt cacagcatag
     7921 atgacgcaaa tacttctgtt gaaagggcta aaagtgcggg atttaataat atttcacttg
     7981 atttgatgat gggaattcct aatcagacaa ttgaaagcct tgaaaaatca atcagtttct
     8041 gtgccgattg caaagttact catatttcat cgtacatttt gaaaattgag gagaatactc
     8101 cgttttataa ggcgcaaaat aaacttaagc ttgccgatga tgatatgcag gctgaaatgt
     8161 atctgaaagc tgttgaaatg cttgattccc tcggatacaa gcaatatgaa atttctaatt
     8221 ttgcaaaaca gggttatgaa agccgacata ataccaatta ctggagatgc ggtgaatata
     8281 tcggcatagg tccgtctgca cactcatttt ttgagggcaa aaggttcttt tattcgagaa
     8341 gtatggacga ttttaataac aataagctgt cttttgaagg tacaggcgga gatgaggagg
     8401 aatttattat gctctctctc aggctgaaaa gcggtcttaa ttattctgaa tttgaggaaa
     8461 aattcggata caccctcccc tcttacatta tcaaaaaagc taaagagtat gaaaaatacg
     8521 gctatacaaa tgttacggac aagtcaatca gctttacacc gaaaggtttt cttgtttcaa
     8581 attcaataat cagtgaactg atataaaaaa cgctccgaga ataaattcgg agcgttaatt
     8641 ttatgttatg aatttgtatg tcagattaat acaatgaagg gtatgaaccg ccgccgataa
     8701 gcgatgtaag aacacttgtt gtaaatgtac ttgtgttaaa tgaccacata gtaagttttg
     8761 cgccgatgaa gaatacaatc ataaatgcaa cggcaacgat gagtgtgaga attaaagtga
     8821 ataatgcaga gttctttgct tcgggaacat tagcttttac ctgatttaca agtgaaataa
     8881 caaggtaaag cataacgatt acgaagaaga acaggaacat atatacgctg attaatgcgc
     8941 aaagacctgc caaaatccaa ccgattgatg ccggaataga ttcaattgaa aatgtaatga
     9001 atgaatcaat aaatgctttg gctgtgtttt cttcggtttt gtatttcttt acatatgcaa
     9061 agagaataac agaatagaag ccgccgataa ggacagcagt aacaagactt acaagaagtg
     9121 ttttcggaaa atcaagtgcg ctcatagaaa gcataagaaa catattgcca agaatgagtg
     9181 caataaagaa aattgccgag aaaagagcgc tgagaatgat gtctttttca gcctttgctg
     9241 ttttgataac agttttggaa tccttaaaga atgaagtaaa cacaacagga atgttcttta
     9301 aagccttaac aaaagcattt tccccaatgg gtgctgtgtt atttacggca taaggcgact
     9361 gctgtgtctg agggctttgc ggctgtgcat actgttgctg aacagggttc tgatactgtg
     9421 gctgttgtgg ctgaacaggc tgctgatact gaggctgtgc ctgtgcattt gcctgctgag
     9481 cctgtgcttg agcggctctt gacttttcgc agttgcaaac agcattgtct tcaagctgtg
     9541 ctccgcaata tttacagaat ttcatggtga ttcctccaag ataaaataat gtgtaacagg
     9601 tcttatagct acctgttgtt tgtttattga gaagtgataa catcaacgct cacagtatat
     9661 cacaaattac agcaataatt caatatttct tacaattttt taatttttta cactacagaa
     9721 aattatatgt taaaataatg aaatgatgta cacatagcaa ataatgacaa taaaacagcg
     9781 gcaaaaacta atgtttaaag tttttgccgc tgtggtttag taataatacc ttataaattt
     9841 tatattgtag taatcacagg ttgtgatgtc gttggtgtca atctcattta taaggatata
     9901 atcctgagca acacctaaaa gatagcctgt tttctgaaca attgtgtttg ctcccatgag
     9961 aaaatcaacg gtgattcgtc ttccgatttg tgttcgcata aaaccgttgt gatatctcag
    10021 attttcggct gttacaggaa acggatattg ataatcactc atcgacattc caatattctg
    10081 ccttatcggc gttgcaacgg tggctccgga gctcgccgtt gtagcagggg ttgcaggcaa
    10141 aacaggtata gatgtatcta ttttttttaa gtccttaatg aacggtatag tttgaagact
    10201 tccgctgtat ttatttatat tttcaggttg ttcttctgat gtacttccgc cctcttcata
    10261 tgctatttct gcctgttcaa gcgagggatt gtcatttgat ttttgaactt tttctgtcat
    10321 attggggtgt gcaacagacg gtgcgccctg attgtgtcgc ataatttcgt caatcgcagg
    10381 aatataacat ccgatatccg ctgtgtttga cggacatgaa ttgttgaggc aggctttgtt
    10441 tttatcaagt ccgtaatgat gttcgggatt aatctgattt gttatctgag ttgtgttaac
    10501 tgtcatattt gaagaattat ccattaagtt atgctccttt atgtttcgga ataagcctcg
    10561 gtaggcgaat aaaagcaatg atcccctacc ctgttgtaaa ttactccgtt gtttgacgga
    10621 aaaaatgttg ggcaggtatc tgaaaatgga ttaaaataga aaattgaatt tccgacagat
    10681 gaatcggtat tgcccgccaa tgcccaatcg gcaatgttat agtgaatttc gtcagggcgt
    10741 atattataaa cattctgagg attatattgt cctccgacag ttgttttaag acaggtaaat
    10801 tgatttggtt gttccattat ggcacggaaa tctccgccct tgctgactct tgcaaattcc
    10861 ccgtctggaa cacgggttcg gtttacaatt accgacgcaa cggcacgcat tccgttttca
    10921 ccttccccac ctgcctcaca ttttaaaagc cttgcaagca attctcttgt actcaatgcc
    10981 accttttttc accaaccgtt attttattca atgatatttt atgcataaat taacttgttg
    11041 ttacaaagaa aaagcttgtg ataaatgtgt tattcacgca gacagaaaat tctgttttat
    11101 agaagcaact cagacggtgt tcgataatct tttgagatgc caactacaac atttattcag
    11161 attagctgtt gctgtctacc gctttacttg cttttgcagg gctattttgc caatcaccga
    11221 accatcagat aaattgtttg ctttgagtaa tattattgat tttttattga cactatcatc
    11281 aatagtgcgt ataatgatat tggaacccga atttttaagt cggctgggta attggtaccc
    11341 tgacttctta aaaatattct gggttctttt tttgtctaaa taaaaaaatc ctgttttccc
    11401 tgttgtttct aaagcaacag tttctttgat taaatcattg atgttgtttt tgccgtcatc
    11461 gttcacaagc caatcatcgt attcttcgtc cattaaaaat ttcagcgtat cgtgtattac
    11521 actggctttt tcatctgtaa aatcataatc ttcatcaagc gagaattttt cttttactcc
    11581 tgcggaaagt tcttgcccaa tctcttgatt aactcctgct ctgttggatt gtccttcatt
    11641 aacttttcca tttttaacag agtttcgtcc gatgtcattg aattgcttac tcttaatgtt
    11701 gtattatccg agtataagtt caaactgttt agtataatct ctgagtaatt gtctaaatac
    11761 tttcttgcta tcataattgt tttcctctaa tttaattata aaatttgcga ttttgttgcc
    11821 atcggttata ttataatcta tatttcggat tgcataaacc ttttctaaag gattatcgtc
    11881 aaaagtattg tcgtagataa ctaatttgta ttgatacttt gagtccactt cacactcaac
    11941 aagaattgag ttatcattta ttcttaatcc cgaatcaagt cctgttgaca tagcgtgcgt
    12001 gaatttccgc cattcttctg ccgttaagac ttcagagaac tttccaccgt gtttaggatt
    12061 tatttcaaat cctaatatta ccaagttaga atgcaatgaa tatcaaaaag aaatggtact
    12121 gcaatcataa caggattttt agattatact tatcaataaa tacagggcgt gaaaataatt
    12181 agccactcat aaatatactc gattttttcg gattaccccc cgactattga tattgagcaa
    12241 aaaaacaccg taattctaac agaactacgg tgttttttat ggcggagacg gtgggattcg
    12301 aacccacgac cctcaggggg catcatgatt tcgagtcatg tccgttatga ccacttcgat
    12361 acgtctccga atattggtga tttaccttgt ttattgtact tgttttttgt gtgattgtca
    12421 agcaaaatta cacaaatttg taaattttaa atttaatccg taaaagcata aataagtgtc
    12481 tgcgattatt atatgaatac ttatgcttga ttttgcggac atttttttga aaatcatgta
    12541 cgaaaagatt attgaaacaa ccatactcaa attatcaatc ggcacaactg cacttgcggg
    12601 attgtcttgc aagactttgt aacagcagag tcatgaacag ccctgttgca gcatatgaaa
    12661 ggcagatata ggcaaattta tcttttggat tttatttaca gcagacggtt ttccttttgc
    12721 aaaaataagc aacctagcaa ttataagcaa cgcttatgcg gattgctgtt ccgaaatttg
    12781 attaagttcc ttctatgctt ttagggtgta ttttccgttt ttgattataa caaaatcctt
    12841 tgccataagt cggtgaagaa gttgcttcga ttttttatga cttattccga gaagttcgga
    12901 aatttctttt gaagttaccg taatgttgtc agtaatgtat gaaattacgg catcctgtct
    12961 gtctgtttca atatcgggac gattttgtaa aatttgagtt ttagttgatt tgctttcagg
    13021 aacaaacgaa agctttaggg tgatgctttc ggggttgaaa ctttcttcaa tgaccggcag
    13081 aacaagtttg tgacttttcc aaacggagaa aatattagaa ataccgaatc cgtcgttact
    13141 gccgattcct atcaaattaa acatacgcat aattgccgtg tttctggggt cggatatacc
    13201 gcccgctctt gcggcgtcga gttcaactct aaatccgccc ggattggata ttgtaatgct
    13261 ttcatcatct ttcataataa caacaccgtt tgaaccataa tagtcggcat ttataaggca
    13321 gtttgcaaga gcttcctgta aggcagttgt aatcggtgta atgtctgatt ttatgtttgc
    13381 tgtcagtttt atatcgtatg aaattttttc aaagaccttt ataaagaaat cataaaggtt
    13441 ttcacagtca gaatttaaat ttgatgaaat aattgtgtgt ttatcatctt gtgttgtttc
    13501 cttatattca agacaatagt acggatattc ttttttgatg aattctgact taccgaacat
    13561 aagaagtcct gcggctgtag ggtgaaacaa aaggtcttcc cctactccta ttgctcctat
    13621 tgcctgcaag aaatctttat ccgacaaatt ttgaagccga ttatttggct taacagttga
    13681 catttttatt cggtagctat ggagtgaatc ggtattaaat acggaagcag tcatgctttc
    13741 gatgatattc atatcctgtg ttttaatctc tgaatcacgc accatagcgt taatttggtc
    13801 gagtgtacag cggtagtcac cctcgccgtt tcttctgtat gaattatgaa tactgccgtc
    13861 aagatacacg ggacggtcaa atcttttggc ttttggcact gtaataacga taatatgctt
    13921 ttcttcaatt ttttgcacat aaacatc
//
